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Predictors of Disease Recurrence Post Living Donor Liver Transplantation in End Stage Chronic HCV Patients
Joint Authors
Abdelhafez, Tawfeek H.
Omran, Moataza H.
El Awady, Mostafa K.
Hunter, Shereen Shoukry
Elbaz, Tamer Mahmoud
Dawood, Reham M.
Abdel Aziz, Ashraf O.
Bader El Din, Noha G.
Abdel Aziz Riad, Mahmoud
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
HCV recurrence represents a universal phenomenon after liver transplantation.
In this study Fifty HCV patients who underwent living donor liver transplantation were enrolled and factors that may accelerate HCV reinfection of the allograft such as donor’s age and degree of liver steatosis, recipient’s age, gender, BMI, MELD score, liver functions, HCV viral load, type of immunosuppressive drug, and genetic polymorphisms of IL28B, OAS, and IL1B were studied.
The results of disease-free survival (DFS) rates showed inverse correlation with the recipient’s postoperative levels of ALT, AST, ALP (P<0.001, <0.001, and 0.006 resp.) as well as pre- and postoperative titers of HCV RNA (P<0.003 and <0.001 resp.).
Recipient’s IL28B SNP was a significant factor in predicting postoperative DFS (P<0.025).
However, SNPs in OAS and IL1B genes had no apparent correlation with DFS.
Cox proportional hazards model revealed that patients with elevated levels of ALT, preoperative viral titers, IL28B CT, and IL28B TT were 8.28, 4.22, 3.35, and 1.36 times, respectively, more likely to develop recurrence.
In conclusion IL28B SNP, ALT level, and preoperative HCV titer besides proper choice of immunosuppressant are helpful for predicting posttransplant HCV recurrence and DFS.
American Psychological Association (APA)
El Awady, Mostafa K.& Bader El Din, Noha G.& Abdel Aziz Riad, Mahmoud& Omran, Moataza H.& Abdelhafez, Tawfeek H.& Elbaz, Tamer Mahmoud…[et al.]. 2014. Predictors of Disease Recurrence Post Living Donor Liver Transplantation in End Stage Chronic HCV Patients. Disease Markers،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-454088
Modern Language Association (MLA)
El Awady, Mostafa K.…[et al.]. Predictors of Disease Recurrence Post Living Donor Liver Transplantation in End Stage Chronic HCV Patients. Disease Markers No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-454088
American Medical Association (AMA)
El Awady, Mostafa K.& Bader El Din, Noha G.& Abdel Aziz Riad, Mahmoud& Omran, Moataza H.& Abdelhafez, Tawfeek H.& Elbaz, Tamer Mahmoud…[et al.]. Predictors of Disease Recurrence Post Living Donor Liver Transplantation in End Stage Chronic HCV Patients. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-454088
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454088