Clinicopathological and Immunohistochemical Characterisation of Gastric Schwannomas in 29 Cases
Joint Authors
Zheng, Lijun
Chen, Chunqiu
Yu, Zhen
Li, Ziyu
Wu, Xiaojiang
Xu, Bin
Bu, Zhaode
Kreis, Martin E.
Feng, Lijin
Ji, Jiafu
Source
Gastroenterology Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Schwannomas are tumors arising from the nervous system that also occur infrequently in the gastrointestinal tract, most commonly in the stomach.
This report characterizes 29 patients with benign or malignant gastric schwannomas.
Surgical data and clinical follow-up information were available for 28 cases with a median postoperative duration of 57 months.
Clinicopathological and immunohistochemical characteristics of benign and malignant schwannomas were analysed.
Four cases (13.7%) were histologically diagnosed with malignant schwannoma.
All tumors were positive for S-100 and CD56 proteins, displaying a diffuse staining pattern.
Vimentin was expressed in 100% cases and all schwannomas were negative for smooth muscle actin, c-kit, and HMB-45.
A significant difference was observed between the group of benign and malignant schwannomas as regards recurrences and metastasis after complete resection (P=0.015).
The survival time of patients with benign schwannomas was longer than the malignant group (P=0.013), so gastric malignant schwannomas have a potential for recurrence and metastasis, with subsequently short survival.
Complete resection with an attempt to remove all tumor tissue with negative margins is of paramount importance in the management of gastric schwannomas, particularly when they turn out to be malignant.
American Psychological Association (APA)
Zheng, Lijun& Wu, Xiaojiang& Kreis, Martin E.& Yu, Zhen& Feng, Lijin& Chen, Chunqiu…[et al.]. 2014. Clinicopathological and Immunohistochemical Characterisation of Gastric Schwannomas in 29 Cases. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-454119
Modern Language Association (MLA)
Zheng, Lijun…[et al.]. Clinicopathological and Immunohistochemical Characterisation of Gastric Schwannomas in 29 Cases. Gastroenterology Research and Practice No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-454119
American Medical Association (AMA)
Zheng, Lijun& Wu, Xiaojiang& Kreis, Martin E.& Yu, Zhen& Feng, Lijin& Chen, Chunqiu…[et al.]. Clinicopathological and Immunohistochemical Characterisation of Gastric Schwannomas in 29 Cases. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-454119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454119