Oleoylethanolamide : A Novel Potential Pharmacological Alternative to Cannabinoid Antagonists for the Control of Appetite
Joint Authors
Moles, Anna
Coccurello, Roberto
Giacovazzo, Giacomo
Romano, Adele
Gaetani, Silvana
Bedse, Gaurav
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The initial pharmaceutical interest for the endocannabinoid system as a target for antiobesity therapies has been restricted by the severe adverse effects of the CB1 antagonist rimonabant.
This study points at oleoylethanolamide (OEA), a monounsaturated analogue, and functional antagonist of anandamide, as a potential and safer antiobesity alternative to CB1 antagonism.
Mice treated with equal doses (5 or 10 mg/kg, i.p.) of OEA or rimonabant were analyzed for the progressive expression of spontaneous behaviors (eating, grooming, rearing, locomotion, and resting) occurring during the development of satiety, according to the paradigm called behavioral satiety sequence (BSS).
Both drugs reduced food (wet mash) intake to a similar extent.
OEA treatment decreased eating activity within the first 30 min and caused a temporary increase of resting time that was not accompanied by any decline of horizontal, vertical and total motor activity.
Besides decreasing eating activity, rimonabant caused a marked increase of the time spent grooming and decreased horizontal motor activity, alterations that might be indicative of aversive nonmotivational effects on feeding.
These results support the idea that OEA suppresses appetite by stimulating satiety and that its profile of action might be predictive of safer effects in humans as a novel antiobesity treatment.
American Psychological Association (APA)
Romano, Adele& Coccurello, Roberto& Giacovazzo, Giacomo& Bedse, Gaurav& Moles, Anna& Gaetani, Silvana. 2014. Oleoylethanolamide : A Novel Potential Pharmacological Alternative to Cannabinoid Antagonists for the Control of Appetite. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-454143
Modern Language Association (MLA)
Romano, Adele…[et al.]. Oleoylethanolamide : A Novel Potential Pharmacological Alternative to Cannabinoid Antagonists for the Control of Appetite. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-454143
American Medical Association (AMA)
Romano, Adele& Coccurello, Roberto& Giacovazzo, Giacomo& Bedse, Gaurav& Moles, Anna& Gaetani, Silvana. Oleoylethanolamide : A Novel Potential Pharmacological Alternative to Cannabinoid Antagonists for the Control of Appetite. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-454143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454143