A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus
Joint Authors
Chen, Lirong
Xu, Xiaojie
Yuan, Gu
Gu, Jiangyong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The use of plants as natural medicines in the treatment of type II diabetes mellitus (T2DM) has long been of special interest.
In this work, we developed a docking score-weighted prediction model based on drug-target network to evaluate the efficacy of medicinal plants for T2DM.
High throughput virtual screening from chemical library of natural products was adopted to calculate the binding affinity between natural products contained in medicinal plants and 33 T2DM-related proteins.
The drug-target network was constructed according to the strength of the binding affinity if the molecular docking score satisfied the threshold.
By linking the medicinal plant with T2DM through drug-target network, the model can predict the efficacy of natural products and medicinal plant for T2DM.
Eighteen thousand nine hundred ninety-nine natural products and 1669 medicinal plants were predicted to be potentially bioactive.
American Psychological Association (APA)
Gu, Jiangyong& Chen, Lirong& Yuan, Gu& Xu, Xiaojie. 2013. A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-454167
Modern Language Association (MLA)
Gu, Jiangyong…[et al.]. A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-454167
American Medical Association (AMA)
Gu, Jiangyong& Chen, Lirong& Yuan, Gu& Xu, Xiaojie. A Drug-Target Network-Based Approach to Evaluate the Efficacy of Medicinal Plants for Type II Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-454167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454167