Human Mesenchymal Stromal Cell-Mediated Immunoregulation : Mechanisms of Action and Clinical Applications
Joint Authors
Dorronsoro, Akaitz
Trigueros, César
Ferrin, Izaskun
Jakobsson, Emma
Fernández-Rueda, Jon
Salcedo, Juan Manuel
Fechter, Karoline
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mesenchymal stromal cells (MSCs) are multipotent cells found in connective tissues that can differentiate into bone, cartilage, and adipose tissue.
Interestingly, they can regulate immune responses in a paracrine way and allogeneic MSCs do not elicit immune response.
These properties have encouraged a number of clinical trials in a broad range of regenerative therapies.
Although these trials were first focused on their differentiation properties, in the last years, the immunosuppressive features have gained most of the attention.
In this review, we will summarize the up-to-date knowledge about the immunosuppressive mechanisms of MSCs in vivo and in vitro and the most promising approaches in clinical investigation.
American Psychological Association (APA)
Dorronsoro, Akaitz& Fernández-Rueda, Jon& Fechter, Karoline& Ferrin, Izaskun& Salcedo, Juan Manuel& Jakobsson, Emma…[et al.]. 2013. Human Mesenchymal Stromal Cell-Mediated Immunoregulation : Mechanisms of Action and Clinical Applications. Bone Marrow Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-454175
Modern Language Association (MLA)
Dorronsoro, Akaitz…[et al.]. Human Mesenchymal Stromal Cell-Mediated Immunoregulation : Mechanisms of Action and Clinical Applications. Bone Marrow Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-454175
American Medical Association (AMA)
Dorronsoro, Akaitz& Fernández-Rueda, Jon& Fechter, Karoline& Ferrin, Izaskun& Salcedo, Juan Manuel& Jakobsson, Emma…[et al.]. Human Mesenchymal Stromal Cell-Mediated Immunoregulation : Mechanisms of Action and Clinical Applications. Bone Marrow Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-454175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454175