Leishmanicidal Activity of Nine Novel Flavonoids from Delphinium staphisagria
Joint Authors
Rosales, María José
Díaz, Jesús G.
Sánchez-Moreno, Manuel
Marín, Clotilde
Ramírez-Macías, Inmaculada
Gutiérrez-Sánchez, Ramón
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Objectives.
To evaluate the in vitro leishmanicidal activity of nine flavonoid derivatives from Delphinium staphisagria against L.
infantum and L.
braziliensis.
Design and Methods.
The in vitro activity of compounds 1–9 was assayed on extracellular promastigote and axenic amastigote forms and on intracellular amastigote forms of the parasites.
Infectivity and cytotoxicity tests were carried on J774.2 macrophage cells using Glucantime as the reference drug.
The mechanisms of action were analysed performing metabolite excretion and transmission electronic microscope ultrastructural alteration studies.
Results.
Nine flavonoids showed leishmanicidal activity against promastigote as well as amastigote forms of Leishmania infantum and L.
braziliensis.
These compounds were nontoxic to mammalian cells and were effective at similar concentrations up to or lower than that of the reference drug (Glucantime).
The results showed that 2″-acetylpetiolaroside (compound 8) was clearly the most active.
Conclusion.
This study has demonstrated that flavonoid derivatives are active against L.
infantum and L.
braziliensis.
American Psychological Association (APA)
Ramírez-Macías, Inmaculada& Marín, Clotilde& Díaz, Jesús G.& Rosales, María José& Gutiérrez-Sánchez, Ramón& Sánchez-Moreno, Manuel. 2012. Leishmanicidal Activity of Nine Novel Flavonoids from Delphinium staphisagria. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-454176
Modern Language Association (MLA)
Ramírez-Macías, Inmaculada…[et al.]. Leishmanicidal Activity of Nine Novel Flavonoids from Delphinium staphisagria. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-454176
American Medical Association (AMA)
Ramírez-Macías, Inmaculada& Marín, Clotilde& Díaz, Jesús G.& Rosales, María José& Gutiérrez-Sánchez, Ramón& Sánchez-Moreno, Manuel. Leishmanicidal Activity of Nine Novel Flavonoids from Delphinium staphisagria. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-454176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454176