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Hepatocellular Carcinoma : Novel Molecular Targets in Carcinogenesis for Future Therapies
Joint Authors
Toro, Adriana
Proiti, Maria
Malaguarnera, Giulia
Bertino, Nicoletta
Demma, Shirin
Gruttadauria, Salvatore
Bertino, Gaetano
Malaguarnera, Michele
Di Carlo, Isidoro
Malaguarnera, Mariano
Ardiri, Annalisa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Hepatocellular carcinoma is one of the most common and lethal malignant tumors worldwide.
Over the past 15 years, the incidence of HCC has more than doubled.
Due to late diagnosis and/or advanced underlying liver cirrhosis, only limited treatment options with marginal clinical benefit are available in up to 70% of patients.
During the last decades, no effective conventional cytotoxic systemic therapy was available contributing to the dismal prognosis in patients with HCC.
A better knowledge of molecular hepatocarcinogenesis provides today the opportunity for targeted therapy.
Materials and Methods.
A search of the literature was made using cancer literature, the PubMed, Scopus, and Web of Science (WOS) database for the following keywords: “hepatocellular carcinoma,” “molecular hepatocarcinogenesis,” “targeted therapy,” and “immunotherapy.” Discussion and Conclusion.
Treatment decisions are complex and dependent upon tumor staging, presence of portal hypertension, and the underlying degree of liver dysfunction.
The knowledge of molecular hepatocarcinogenesis broadened the horizon for patients with advanced HCC.
During the last years, several molecular targeted agents have been evaluated in clinical trials in advanced HCC.
In the future, new therapeutic options will be represented by a blend of immunotherapy-like vaccines and T-cell modulators, supplemented by molecularly targeted inhibitors of tumor signaling pathways.
American Psychological Association (APA)
Bertino, Gaetano& Demma, Shirin& Ardiri, Annalisa& Proiti, Maria& Gruttadauria, Salvatore& Toro, Adriana…[et al.]. 2014. Hepatocellular Carcinoma : Novel Molecular Targets in Carcinogenesis for Future Therapies. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-454184
Modern Language Association (MLA)
Bertino, Gaetano…[et al.]. Hepatocellular Carcinoma : Novel Molecular Targets in Carcinogenesis for Future Therapies. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-454184
American Medical Association (AMA)
Bertino, Gaetano& Demma, Shirin& Ardiri, Annalisa& Proiti, Maria& Gruttadauria, Salvatore& Toro, Adriana…[et al.]. Hepatocellular Carcinoma : Novel Molecular Targets in Carcinogenesis for Future Therapies. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-454184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454184