CD28 Family and Chronic Rejection : “To Belatacept...and Beyond!”
Joint Authors
Castellano, Lúcio Roberto
Corrêa, Rosana Rosa Miranda
Vinícius da Silva, Marcos
Rocha, Laura Penna
Reis, Marlene Antônia dos
Machado, Juliana Reis
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-07
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Kidneys are one of the most frequently transplanted human organs.
Immunosuppressive agents may prevent or reverse most acute rejection episodes; however, the graft may still succumb to chronic rejection.
The immunological response involved in the chronic rejection process depends on both innate and adaptive immune response.
T lymphocytes have a pivotal role in chronic rejection in adaptive immune response.
Meanwhile, we aim to present a general overview on the state-of-the-art knowledge of the strategies used for manipulating the lymphocyte activation mechanisms involved in allografts, with emphasis on T-lymphocyte costimulatory and coinhibitory molecules of the B7-CD28 superfamily.
A deeper understanding of the structure and function of these molecules improves both the knowledge of the immune system itself and their potential action as rejection inducers or tolerance promoters.
In this context, the central role played by CD28 family, especially the relationship between CD28 and CTLA-4, becomes an interesting target for the development of immune-based therapies aiming to increase the survival rate of allografts and to decrease autoimmune phenomena.
Good results obtained by the recent development of abatacept and belatacept with potential clinical use aroused better expectations concerning the outcome of transplanted patients.
American Psychological Association (APA)
Vinícius da Silva, Marcos& Machado, Juliana Reis& Rocha, Laura Penna& Castellano, Lúcio Roberto& Reis, Marlene Antônia dos& Corrêa, Rosana Rosa Miranda. 2012. CD28 Family and Chronic Rejection : “To Belatacept...and Beyond!”. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-454192
Modern Language Association (MLA)
Vinícius da Silva, Marcos…[et al.]. CD28 Family and Chronic Rejection : “To Belatacept...and Beyond!”. Journal of Transplantation No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-454192
American Medical Association (AMA)
Vinícius da Silva, Marcos& Machado, Juliana Reis& Rocha, Laura Penna& Castellano, Lúcio Roberto& Reis, Marlene Antônia dos& Corrêa, Rosana Rosa Miranda. CD28 Family and Chronic Rejection : “To Belatacept...and Beyond!”. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-454192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454192