Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis
Joint Authors
Oliveira, Luciana Souza
Vieira, Leda Quercia
Macêdo, Juan Pereira
Mendes, Bárbara Pinheiro
Noronha, Fátima Soares Motta
Roma, Eric Henrique
Horta, Maria Fátima
Duarte, Myrian Morato
Source
Journal of Parasitology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cutaneous leishmaniasis affects millions of people around the world.
Several species of Leishmania infect mouse strains, and murine models closely reproduce the cutaneous lesions caused by the parasite in humans.
Mouse models have enabled studies on the pathogenesis and effector mechanisms of host resistance to infection.
Here, we review the role of nitric oxide (NO), reactive oxygen species (ROS), and peroxynitrite (ONOO−) in the control of parasites by macrophages, which are both the host cells and the effector cells.
We also discuss the role of neutrophil-derived oxygen and nitrogen reactive species during infection with Leishmania.
We emphasize the role of these cells in the outcome of leishmaniasis early after infection, before the adaptive Th-cell immune response.
American Psychological Association (APA)
Horta, Maria Fátima& Mendes, Bárbara Pinheiro& Roma, Eric Henrique& Noronha, Fátima Soares Motta& Macêdo, Juan Pereira& Oliveira, Luciana Souza…[et al.]. 2012. Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-454198
Modern Language Association (MLA)
Horta, Maria Fátima…[et al.]. Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis. Journal of Parasitology Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-454198
American Medical Association (AMA)
Horta, Maria Fátima& Mendes, Bárbara Pinheiro& Roma, Eric Henrique& Noronha, Fátima Soares Motta& Macêdo, Juan Pereira& Oliveira, Luciana Souza…[et al.]. Reactive Oxygen Species and Nitric Oxide in Cutaneous Leishmaniasis. Journal of Parasitology Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-454198
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454198