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Evaluation of the Cytotoxicity of Satureja spicigera and Its Main Compounds
Joint Authors
Moradi-Afrapoli, Fahimeh
Tavajohi, Shohreh
Saeidnia, Soodabeh
Malmir, Maryam
Akbari, Hassan
Ostad, Seyed Nasser
Gohari, Ahmad Reza
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Satureja spicigera (Lamiaceae) grows wildly in Northwest of Iran.
In this study, bioassay-guided isolation and identification of the main compounds has been reported using various chromatographic methods and comparison of their spectral data with those reported in the literature.
Brine shrimp lethality and four cancerous cell lines HT29/219, Caco2, NIH-3T3, and T47D were used for cytotoxicity evaluations.
From the aerial parts of S.
spicigera, nine known compounds including two flavanones, 5,7,3′,5′-tetrahydroxy flavanone (8) and 5,4′-dihydroxy-3′-methoxyflavanone-7-(6′′-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside (9), one dihydrochalcone, nubigenol (7), together with thymoquinone (1), thymol (2), carvacrol (3), β-sitosterol (4), ursolic acid (5) and oleanolic acid (6) were identified.
Among the isolated chalcone and flavanones, compound 8 was effective against Artemia salina larva (LC50= 2 μg/mL) and only the compound 9 demonstrated IC50 value of 98.7 μg/mL on the T47D (human, breast, ductal carcinoma).
Other compounds did not show significant inhibition of the cell growth.
American Psychological Association (APA)
Gohari, Ahmad Reza& Ostad, Seyed Nasser& Moradi-Afrapoli, Fahimeh& Malmir, Maryam& Tavajohi, Shohreh& Akbari, Hassan…[et al.]. 2012. Evaluation of the Cytotoxicity of Satureja spicigera and Its Main Compounds. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-454203
Modern Language Association (MLA)
Gohari, Ahmad Reza…[et al.]. Evaluation of the Cytotoxicity of Satureja spicigera and Its Main Compounds. The Scientific World Journal No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-454203
American Medical Association (AMA)
Gohari, Ahmad Reza& Ostad, Seyed Nasser& Moradi-Afrapoli, Fahimeh& Malmir, Maryam& Tavajohi, Shohreh& Akbari, Hassan…[et al.]. Evaluation of the Cytotoxicity of Satureja spicigera and Its Main Compounds. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-454203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454203