Trail Overexpression Inversely Correlates with Histological Differentiation in Intestinal-Type Sinonasal Adenocarcinoma
Joint Authors
Lo Muzio, Lorenzo
Rubini, Corrado
Mascitti, M.
Re, M.
Santarelli, A.
Zizzi, A.
Bambini, F.
Source
International Journal of Surgical Oncology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Despite their histological resemblance to colorectal adenocarcinoma, there is some information about the molecular events involved in the pathogenesis of intestinal-type sinonasal adenocarcinomas (ITACs).
To evaluate the possible role of TNF-related apoptosis-inducing ligand (TRAIL) gene defects in ITAC, by investigating the immunohistochemical expression of TRAIL gene product in a group of ethmoidal ITACs associated with occupational exposure.
Material and Methods.
Retrospective study on 23 patients with pathological diagnosis of primary ethmoidal ITAC.
Representative formalin-fixed, paraffin-embedded block from each case was selected for immunohistochemical studies using the antibody against TRAIL.
Clinicopathological data were also correlated with the staining results.
Results.
The immunohistochemical examination demonstrated that poorly differentiated cases showed a higher percentage of TRAIL expressing cells compared to well-differentiated cases.
No correlation was found with other clinicopathological parameters, including T, stage and relapses.
Conclusion.
The relationship between upregulation of TRAIL and poorly differentiated ethmoidal adenocarcinomas suggests that the mutation of this gene, in combination with additional genetic events, could play a role in the pathogenesis of ITAC.
American Psychological Association (APA)
Re, M.& Santarelli, A.& Mascitti, M.& Bambini, F.& Lo Muzio, Lorenzo& Zizzi, A.…[et al.]. 2013. Trail Overexpression Inversely Correlates with Histological Differentiation in Intestinal-Type Sinonasal Adenocarcinoma. International Journal of Surgical Oncology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-454205
Modern Language Association (MLA)
Re, M.…[et al.]. Trail Overexpression Inversely Correlates with Histological Differentiation in Intestinal-Type Sinonasal Adenocarcinoma. International Journal of Surgical Oncology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-454205
American Medical Association (AMA)
Re, M.& Santarelli, A.& Mascitti, M.& Bambini, F.& Lo Muzio, Lorenzo& Zizzi, A.…[et al.]. Trail Overexpression Inversely Correlates with Histological Differentiation in Intestinal-Type Sinonasal Adenocarcinoma. International Journal of Surgical Oncology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-454205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454205