![](/images/graphics-bg.png)
Sarcopenic Obesity and Endocrinal Adaptation with Age
Joint Authors
Yamaguchi, Akihiko
Sakuma, Kunihiro
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In normal aging, changes in the body composition occur that result in a shift toward decreased muscle mass and increased fat mass.
The loss of muscle mass that occurs with aging is termed sarcopenia and is an important cause of frailty, disability, and loss of independence in older adults.
Age-related changes in the body composition as well as the increased prevalence of obesity determine a combination of excess weight and reduced muscle mass or strength, recently defined as sarcopenic obesity.
Weight gain increases total/abdominal fat, which, in turn, elicits inflammation and fatty infiltration in muscle.
Sarcopenic obesity appears to be linked with the upregulation of TNF-α, interleukin (IL)-6, leptin, and myostatin and the downregulation of adiponectin and IL-15.
Multiple combined exercise and mild caloric restriction markedly attenuate the symptoms of sarcopenic obesity.
Intriguingly, the inhibition of myostatin induced by gene manipulation or neutralizing antibody ameliorates sarcopenic obesity via increased skeletal muscle mass and improved glucose homeostasis.
In this review, we describe the possible influence of endocrinal changes with age on sarcopenic obesity.
American Psychological Association (APA)
Sakuma, Kunihiro& Yamaguchi, Akihiko. 2013. Sarcopenic Obesity and Endocrinal Adaptation with Age. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-454229
Modern Language Association (MLA)
Sakuma, Kunihiro& Yamaguchi, Akihiko. Sarcopenic Obesity and Endocrinal Adaptation with Age. International Journal of Endocrinology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-454229
American Medical Association (AMA)
Sakuma, Kunihiro& Yamaguchi, Akihiko. Sarcopenic Obesity and Endocrinal Adaptation with Age. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-454229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454229