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Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors
Joint Authors
Heneka, Michael T.
Tatenhorst, Lars
Hahnen, Eric
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-08-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The peroxisome proliferator-activated receptors (PPARs) are ligand-inducible transcription factors which belong to the superfamily of nuclear hormone receptors.
In recent years it turned out that natural as well as synthetic PPAR agonists exhibit profound antineoplastic as well as redifferentiation effects in tumors of the central nervous system (CNS).
The molecular understanding of the underlying mechanisms is still emerging, with partially controverse findings reported by a number of studies dealing with the influence of PPARs on treatment of tumor cells in vitro.
Remarkably, studies examining the effects of these drugs in vivo are just beginning to emerge.
However, the agonists of PPARs, in particular the thiazolidinediones, seem to be promising candidates for new approaches in human CNS tumor therapy.
American Psychological Association (APA)
Tatenhorst, Lars& Hahnen, Eric& Heneka, Michael T.. 2008. Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors. PPAR Research،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-454248
Modern Language Association (MLA)
Tatenhorst, Lars…[et al.]. Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors. PPAR Research No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-454248
American Medical Association (AMA)
Tatenhorst, Lars& Hahnen, Eric& Heneka, Michael T.. Peroxisome Proliferator-Activated Receptors (PPARs) as Potential Inducers of Antineoplastic Effects in CNS Tumors. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-454248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454248