Effect of Staged Preconditioning on Biochemical Markers in the Patients Undergoing Coronary Artery Bypass Grafting

Abstract EN

The present study has investigated the effectiveness of staged-preconditioning, in both remote and target organs.

After IP the myocardial release of the biochemical markers including, creatine phosphokinase (CPK), cardiac creatine kinase (CK-MB), cardiac troponin T (cTnT) and lactate dehydrogenase (LDH) were evaluated in patients who underwent CABG, with and without staged-preconditioning.

Sixty-one patients entered the study; there were 32 patients in the staged-preconditioning group and 29 patients in the control group.

All patients underwent on-pump CABG using cardiopulmonary bypass (CPB) techniques.

In the staged-preconditioning group, patients underwent two stages of IP on remote (upper limb) and target organs.

Each stage of preconditioning was carried out by 3 cycles of ischemia and then reperfusion.

Serum levels of biochemical markers were immediately measured postoperatively at 24, 48 and 72 h.

Serum CK-MB, CPK and LDH levels were significantly lower in the staged-preconditioning group than in the control group.

The CK-MB release in the staged-preconditioning patients reduced by 51% in comparison with controls over 72 h after CABG.

These results suggest that myocardial injury was attenuated by the effect of three rounds of both remote and target organ IP.