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Expression of Constitutive Nitric Oxide Synthase Isoforms in Varicose Vein Wall; Preliminary Results
Joint Authors
Haviarová, Zora
Janegová, Andrea
Kováč, Peter
Janega, Pavel
Mráz, Peter
Durdík, Štefan
Štvrtinová, Viera
Source
International Journal of Vascular Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
There are conflicting findings in literature about the structural changes of the primary varicose veins.
NO (a potent vasodilatator) is synthesized by nitric oxide synthase (NOS).
From 3 known NOS isoforms the two are constitutional: eNOS (endothelial NOS) and nNOS (neuronal NOS).
10 varicose and 10 control vein samples were processed by standard light microscopy and immuno-histochemica techniques using rabbit polyclonal antibodies against eNOS and nNOS.
Antibodies expression was evaluated semiquantitatively and proved morphometrically by 2D-image analysis.
total area of NOS isoforms expressions was determined by color analysis and color digital subtraction.
The results showed discontinuous and significantly lower expression of both NOS isoforms the in the tunica media of varicose veins compared with the control group.
For the statistical analysis the unpaired t-test was used.
Our results suppose lower NO levels in varicose vein wall, deducing that varicose dilatation is due to other mechanism, and they contradict the results of previously published similar works.
American Psychological Association (APA)
Haviarová, Zora& Janegová, Andrea& Janega, Pavel& Durdík, Štefan& Kováč, Peter& Štvrtinová, Viera…[et al.]. 2011. Expression of Constitutive Nitric Oxide Synthase Isoforms in Varicose Vein Wall; Preliminary Results. International Journal of Vascular Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-454270
Modern Language Association (MLA)
Haviarová, Zora…[et al.]. Expression of Constitutive Nitric Oxide Synthase Isoforms in Varicose Vein Wall; Preliminary Results. International Journal of Vascular Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-454270
American Medical Association (AMA)
Haviarová, Zora& Janegová, Andrea& Janega, Pavel& Durdík, Štefan& Kováč, Peter& Štvrtinová, Viera…[et al.]. Expression of Constitutive Nitric Oxide Synthase Isoforms in Varicose Vein Wall; Preliminary Results. International Journal of Vascular Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-454270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454270