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Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks
Joint Authors
Moore, Ernest J.
Gopal, Kamakshi V.
Gross, Guenter W.
Wu, Calvin
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Styrene oxide (SO) (C8H8O), the major metabolite of styrene (C6H5CH=CH2), is widely used in industrial applications.
Styrene and SO are neurotoxic and cause damaging effects on the auditory system.
However, little is known about their concentration-dependent electrophysiological and morphological effects.
We used spontaneously active auditory cortex networks (ACNs) growing on microelectrode arrays (MEA) to characterize neurotoxic effects of SO.
Acute application of 0.1 to 3.0 mM SO showed concentration-dependent inhibition of spike activity with no noticeable morphological changes.
The spike rate IC50 (concentration inducing 50% inhibition) was 511±60 μM (n=10).
Subchronic (5 hr) single applications of 0.5 mM SO also showed 50% activity reduction with no overt changes in morphology.
The results imply that electrophysiological toxicity precedes cytotoxicity.
Five-hour exposures to 2 mM SO revealed neuronal death, irreversible activity loss, and pronounced glial swelling.
Paradoxical “protection” by 40 μM bicuculline suggests binding of SO to GABA receptors.
American Psychological Association (APA)
Gopal, Kamakshi V.& Wu, Calvin& Moore, Ernest J.& Gross, Guenter W.. 2011. Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks. ISRN Otolaryngology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-454278
Modern Language Association (MLA)
Gopal, Kamakshi V.…[et al.]. Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks. ISRN Otolaryngology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-454278
American Medical Association (AMA)
Gopal, Kamakshi V.& Wu, Calvin& Moore, Ernest J.& Gross, Guenter W.. Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks. ISRN Otolaryngology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-454278
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454278