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Evaluation of the DDSolver Software Applications
Joint Authors
Bou-Chacra, Nádia
Gao, Yuan
Zuo, Jieyu
Löbenberg, Raimar
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
When a new oral dosage form is developed, its dissolution behavior must be quantitatively analyzed.
Dissolution analysis involves a comparison of the dissolution profiles and the application of mathematical models to describe the drug release pattern.
This report aims to assess the application of the DDSolver, an Excel add-in software package, which is designed to analyze data obtained from dissolution experiments.
The data used in this report were chosen from two dissolution studies.
The results of the DDSolver analysis were compared with those obtained using an Excel worksheet.
The comparisons among three different products obtained similarity factors (f2) of 23.21, 46.66, and 17.91 using both DDSolver and the Excel worksheet.
The results differed when DDSolver and Excel were used to calculate the release exponent “n” in the Korsmeyer-Peppas model.
Performing routine quantitative analysis proved to be much easier using the DDSolver program than an Excel spreadsheet.
The use of the DDSolver program reduced the calculation time and has the potential to omit calculation errors, thus making this software package a convenient tool for dissolution comparison.
American Psychological Association (APA)
Zuo, Jieyu& Gao, Yuan& Bou-Chacra, Nádia& Löbenberg, Raimar. 2014. Evaluation of the DDSolver Software Applications. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-454292
Modern Language Association (MLA)
Zuo, Jieyu…[et al.]. Evaluation of the DDSolver Software Applications. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-454292
American Medical Association (AMA)
Zuo, Jieyu& Gao, Yuan& Bou-Chacra, Nádia& Löbenberg, Raimar. Evaluation of the DDSolver Software Applications. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-454292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454292