![](/images/graphics-bg.png)
Tumor Lymphangiogenesis as a Potential Therapeutic Target
Joint Authors
Duong, Tam
Koopman, Peter
Francois, Mathias
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-16
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Metastasis the spread of cancer cells to distant organs, is the main cause of death for cancer patients.
Metastasis is often mediated by lymphatic vessels that invade the primary tumor, and an early sign of metastasis is the presence of cancer cells in the regional lymph node (the first lymph node colonized by metastasizing cancer cells from a primary tumor).
Understanding the interplay between tumorigenesis and lymphangiogenesis (the formation of lymphatic vessels associated with tumor growth) will provide us with new insights into mechanisms that modulate metastatic spread.
In the long term, these insights will help to define new molecular targets that could be used to block lymphatic vessel-mediated metastasis and increase patient survival.
Here, we review the molecular mechanisms of embryonic lymphangiogenesis and those that are recapitulated in tumor lymphangiogenesis, with a view to identifying potential targets for therapies designed to suppress tumor lymphangiogenesis and hence metastasis.
American Psychological Association (APA)
Duong, Tam& Koopman, Peter& Francois, Mathias. 2012. Tumor Lymphangiogenesis as a Potential Therapeutic Target. Journal of Oncology،Vol. 2012, no. 2012, pp.1-23.
https://search.emarefa.net/detail/BIM-454297
Modern Language Association (MLA)
Duong, Tam…[et al.]. Tumor Lymphangiogenesis as a Potential Therapeutic Target. Journal of Oncology No. 2012 (2012), pp.1-23.
https://search.emarefa.net/detail/BIM-454297
American Medical Association (AMA)
Duong, Tam& Koopman, Peter& Francois, Mathias. Tumor Lymphangiogenesis as a Potential Therapeutic Target. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-23.
https://search.emarefa.net/detail/BIM-454297
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454297