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The Add-On Effect of Solifenacin for Patients with Remaining Overactive Bladder after Treatment with Tamsulosin for Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction
Joint Authors
Masumori, Naoya
Aoki, Masaharu
Tsukamoto, Taiji
Yanase, Masahiro
Horita, Hiroki
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objectives.
To investigate the add-on effect of solifenacin for Japanese men with remaining overactive bladder (OAB) symptoms after tamsulosin monotherapy for lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction (BPO) in real-life clinical practice.
Methods.
Patients aged ≥ 50 having remaining OAB symptoms (≥ 3 of OAB symptom score (OABSS) with ≥2 of urgency score) after at least 4 weeks treatment by 0.2 mg of tamsulosin for BPO/LUTS received 2.5 or 5.0 mg of solifenacin for 12 weeks.
The International Prostate Symptom Score (IPSS), QOL index and OABSS, maximum flow rate (Qmax) and postvoid residual urine volume (PVR) were determined.
Results.
A total of 48 patients (mean age 72.5 years) completed the study.
There were significant improvement in IPSS (15.1 to 11.2) and QOL index (4.2 to 3.0) by add-on of solifenacin.
Although the IPSS storage symptom score was significantly improved, there were no changes observed in the IPSS voiding symptom score.
The OABSS showed significant improvement (8.0 to 4.8).
No changes were observed in Qmax and PVR.
Conclusions.
Under the supervision of an experienced urologist, the additional administration of solifenacin to patients with BPO/LUTS treated with tamsulosin, is effective in controlling remaining OAB symptoms.
American Psychological Association (APA)
Masumori, Naoya& Tsukamoto, Taiji& Yanase, Masahiro& Horita, Hiroki& Aoki, Masaharu. 2010. The Add-On Effect of Solifenacin for Patients with Remaining Overactive Bladder after Treatment with Tamsulosin for Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction. Advances in Urology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-454328
Modern Language Association (MLA)
Masumori, Naoya…[et al.]. The Add-On Effect of Solifenacin for Patients with Remaining Overactive Bladder after Treatment with Tamsulosin for Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction. Advances in Urology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-454328
American Medical Association (AMA)
Masumori, Naoya& Tsukamoto, Taiji& Yanase, Masahiro& Horita, Hiroki& Aoki, Masaharu. The Add-On Effect of Solifenacin for Patients with Remaining Overactive Bladder after Treatment with Tamsulosin for Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction. Advances in Urology. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-454328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454328