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Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder
Joint Authors
Ashwood, Paul
Van de Water, Judy
Onore, Charity
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder estimated to affect 1 in 110 children in the U.S., yet the pathology of this disorder is not fully understood.
Abnormal levels of several growth factors have been demonstrated in adults with ASD, including epidermal growth factor (EGF) and hepatocyte growth factor (HGF).
Both of these growth factors serve important roles in neurodevelopment and immune function.
In this study, concentrations of EGF and HGF were assessed in the plasma of 49 children with ASD aged 2–4 years old and 31 typically developing controls of a similar age as part of the Autism Phenome Project (APP).
Levels of EGF were significantly reduced in the ASD group compared to typically developing controls (P=0.003).
There were no significant differences in HGF levels in young children with ASD and typically developing controls.
EGF plays an important role in regulating neural growth, proliferation, differentiation and migration, and reduced levels of this molecule may negatively impact neurodevelopment in young children with ASD.
American Psychological Association (APA)
Onore, Charity& Van de Water, Judy& Ashwood, Paul. 2012. Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder. Autism Research and Treatment،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-454341
Modern Language Association (MLA)
Onore, Charity…[et al.]. Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder. Autism Research and Treatment No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-454341
American Medical Association (AMA)
Onore, Charity& Van de Water, Judy& Ashwood, Paul. Decreased Levels of EGF in Plasma of Children with Autism Spectrum Disorder. Autism Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-454341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454341