MicroRNAs Regulate Key Effector Pathways of Senescence
Joint Authors
LLeonart, Matilde E.
Kondoh, Hiroshi
Feliciano, Andrea
Sánchez-Sendra, Beatriz
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
MicroRNAs (miRNAs) are small (approximately 22 nt) noncoding endogenous RNA molecules that regulate gene expression and protein coding by base pairing with the 3′ untranslated region (UTR) of target mRNAs.
miRNA expression is associated with cancer pathogenesis because miRNAs are intimately linked to cancer development.
Senescence blocks cell proliferation, representing an important barrier that cells must bypass to reach malignancy.
Importantly, certain miRNAs have been shown to have an important role during cellular senescence, which is also involved in human tumorigenesis.
Therefore, therapeutic induction of senescence by drugs or miRNA-based therapies is a potential method to treat cancer by inducing a persistent growth arrest in tumors.
American Psychological Association (APA)
Feliciano, Andrea& Sánchez-Sendra, Beatriz& Kondoh, Hiroshi& LLeonart, Matilde E.. 2011. MicroRNAs Regulate Key Effector Pathways of Senescence. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-454342
Modern Language Association (MLA)
Feliciano, Andrea…[et al.]. MicroRNAs Regulate Key Effector Pathways of Senescence. Journal of Aging Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-454342
American Medical Association (AMA)
Feliciano, Andrea& Sánchez-Sendra, Beatriz& Kondoh, Hiroshi& LLeonart, Matilde E.. MicroRNAs Regulate Key Effector Pathways of Senescence. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-454342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454342
