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Cardiomyocyte Triglyceride Accumulation and Reduced Ventricular Function in Mice with Obesity Reflect Increased Long Chain Fatty Acid Uptake and De Novo Fatty Acid Synthesis
Joint Authors
Homma, Shunichi
Arai, Kotaro
Hyodo, Eiichi
Zhou, Shengli
Hu, Chunguang
Walewski, José L.
Berk, Paul D.
Ge, Fengxia
Lobdell IV, Harrison
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
A nonarteriosclerotic cardiomyopathy is increasingly seen in obese patients.
Seeking a rodent model, we studied cardiac histology, function, cardiomyocyte fatty acid uptake, and transporter gene expression in male C57BL/6J control mice and three obesity groups: similar mice fed a high-fat diet (HFD) and db/db and ob/ob mice.
At sacrifice, all obesity groups had increased body and heart weights and fatty livers.
By echocardiography, ejection fraction (EF) and fractional shortening (FS) of left ventricular diameter during systole were significantly reduced.
The Vmax for saturable fatty acid uptake was increased and significantly correlated with cardiac triglycerides and insulin concentrations.
Vmax also correlated with expression of genes for the cardiac fatty acid transporters Cd36 and Slc27a1.
Genes for de novo fatty acid synthesis (Fasn, Scd1) were also upregulated.
Ten oxidative phosphorylation pathway genes were downregulated, suggesting that a decrease in cardiomyocyte ATP synthesis might explain the decreased contractile function in obese hearts.
American Psychological Association (APA)
Ge, Fengxia& Hu, Chunguang& Hyodo, Eiichi& Arai, Kotaro& Zhou, Shengli& Lobdell IV, Harrison…[et al.]. 2011. Cardiomyocyte Triglyceride Accumulation and Reduced Ventricular Function in Mice with Obesity Reflect Increased Long Chain Fatty Acid Uptake and De Novo Fatty Acid Synthesis. Journal of Obesity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-454360
Modern Language Association (MLA)
Ge, Fengxia…[et al.]. Cardiomyocyte Triglyceride Accumulation and Reduced Ventricular Function in Mice with Obesity Reflect Increased Long Chain Fatty Acid Uptake and De Novo Fatty Acid Synthesis. Journal of Obesity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-454360
American Medical Association (AMA)
Ge, Fengxia& Hu, Chunguang& Hyodo, Eiichi& Arai, Kotaro& Zhou, Shengli& Lobdell IV, Harrison…[et al.]. Cardiomyocyte Triglyceride Accumulation and Reduced Ventricular Function in Mice with Obesity Reflect Increased Long Chain Fatty Acid Uptake and De Novo Fatty Acid Synthesis. Journal of Obesity. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-454360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454360