Low Density Lipoprotein-Containing Circulating Immune Complexes : Role in Atherosclerosis and Diagnostic Value
Joint Authors
Bobryshev, Yuri V.
Kaikkonen, Jari
Orekhov, Alexander N.
Salonen, Jukka T.
Sobenin, Igor A.
Melnichenko, Alexandra A.
Zhelankin, Andrey V.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
It has been suggested that low density lipoprotein-containing circulating immune complexes (LDL-CIC) play a role in atherogenesis and are involved in the formation of early atherosclerotic lesion.
These complexes, as well as anti-LDL autoantibodies, have been found in the blood and in the atherosclerotic lesions of patients with different cardiovascular diseases, as well as in the blood of animals with experimental atherosclerosis.
It can be suggested that the presence of anti-LDL antibodies in the blood is a result of immune response induced by lipoprotein modification.
LDL-CIC differs from native LDL in many aspects.
It has much lower sialic acid content, smaller diameter, and higher density and is more electronegative than native LDL.
Fraction of LDL-CICs is fundamental to the serum atherogenicity manifested at the cellular level.
LDL-CIC, unlike native LDL, is able to induce intracellular accumulation of neutral lipids, especially esterified cholesterol, in cells cultured from uninvolved human aortic intima and in macrophage cultures.
After removal of LDL-CIC, the CHD patient’s sera lose their atherogenic properties.
Titer of LDL-CIC in blood serum significantly correlates with progression of atherosclerosis in human in vivo and has the highest diagnostic value among other measured serum lipid parameters.
Elevated CIC-cholesterol might well be a possible risk factor of coronary atherosclerosis.
American Psychological Association (APA)
Sobenin, Igor A.& Salonen, Jukka T.& Zhelankin, Andrey V.& Melnichenko, Alexandra A.& Kaikkonen, Jari& Bobryshev, Yuri V.…[et al.]. 2014. Low Density Lipoprotein-Containing Circulating Immune Complexes : Role in Atherosclerosis and Diagnostic Value. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-454365
Modern Language Association (MLA)
Sobenin, Igor A.…[et al.]. Low Density Lipoprotein-Containing Circulating Immune Complexes : Role in Atherosclerosis and Diagnostic Value. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-454365
American Medical Association (AMA)
Sobenin, Igor A.& Salonen, Jukka T.& Zhelankin, Andrey V.& Melnichenko, Alexandra A.& Kaikkonen, Jari& Bobryshev, Yuri V.…[et al.]. Low Density Lipoprotein-Containing Circulating Immune Complexes : Role in Atherosclerosis and Diagnostic Value. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-454365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454365