Association of Polymorphisms in Mitofusin-2 Gene with Type 2 Diabetes in Han Chinese

Abstract EN

MFN2 and ESRRA are candidate genes involved in the pathogenesis of T2D.

Five tag-SNPs in MFN2 gene and three in ESRRA gene were selected and genotyped with TaqMan or PCR-RFLP method in stage 1 populations (555 patients with T2D and 649 control subjects) and stage 2 populations (546 patients with T2D versus 419 control subjects) in Han Chinese.

And combining our published data, we estimated the interactions between genetic variants in the MFN2, ESRRA, and PGC-1α genes on the T2D risk using MDR.

rs873458 (G>A) and rs2878677 (C>T) in MFN2 gene were significantly associated with T2D (P=0.005 and 0.01) in stage 1 populations, and the association of other SNPs with T2D was not found.

In stage 2 populations, we further confirmed the association between rs2878677 and T2D (P=0.01).

Combining the two stage populations, the data supported more significant effect of rs873458 and rs2878677 on T2D risk (P=0.003 and 0.0001).

A-C-G-T-C and G-T-C-T-C in MFN2 had significant association with T2D (P=0.007 and 0.009).

The present study also provided the evidence that MFN2 had interactions with PGC-1α (P<0.0001) or ESRRA (P<0.0001).

This study suggested a role of MFN2 polymorphism in the risk of T2D; however, further studies are needed.