Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle
Joint Authors
Song, Shijie
Sava, Vasyl
Song, Shuojing
Lin, Xiaoyang
Sanchez-Ramos, Juan
Li, Kunyu
Cao, Chuanhai
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
We tested the hypothesis that transient microinjury to the brain elicits cellular and humoral responses that stimulate hippocampal neurogenesis.
Brief stereotaxic insertion and removal of a microneedle into the right hippocampus resulted in (a) significantly increased expression of granulocyte-colony stimulating factor (G-CSF), the chemokine MIP-1a, and the proinflammatory cytokine IL12p40; (b) pronounced activation of microglia and astrocytes; and (c) increase in hippocampal neurogenesis.
This study describes immediate and early humoral and cellular mechanisms of the brain’s response to microinjury that will be useful for the investigation of potential neuroprotective and deleterious effects of deep brain stimulation in various neuropsychiatric disorders.
American Psychological Association (APA)
Song, Shijie& Song, Shuojing& Cao, Chuanhai& Lin, Xiaoyang& Li, Kunyu& Sava, Vasyl…[et al.]. 2013. Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle. Stem Cells International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-454382
Modern Language Association (MLA)
Song, Shijie…[et al.]. Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle. Stem Cells International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-454382
American Medical Association (AMA)
Song, Shijie& Song, Shuojing& Cao, Chuanhai& Lin, Xiaoyang& Li, Kunyu& Sava, Vasyl…[et al.]. Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle. Stem Cells International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-454382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454382