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Investigation of Potent Lead for Acquired Immunodeficiency Syndrome from Traditional Chinese Medicine
Joint Authors
Lee, Wen-Yuan
Chen, Kuen-Bao
Chen, Calvin Yu-Chian
Hung, Tzu-Chieh
Chan, Yueh-Chiu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Acquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus (HIV), has become, because of the rapid spread of the disease, a serious global problem and cannot be treated.
Recent studies indicate that VIF is a protein of HIV to prevent all of human immunity to attack HIV.
Molecular compounds of traditional Chinese medicine (TCM) database filtered through molecular docking and molecular dynamics simulations to inhibit VIF can protect against HIV.
Glutamic acid, plantagoguanidinic acid, and Aurantiamide acetate based docking score higher with other TCM compounds selected.
Molecular dynamics are useful for analysis and detection ligand interactions.
According to the docking position, hydrophobic interactions, hydrogen bonding changes, and structure variation, the study try to select the efficacy of traditional Chinese medicine compound Aurantiamide acetate is better than the other for protein-ligand interactions to maintain the protein composition, based on changes in the structure.
American Psychological Association (APA)
Hung, Tzu-Chieh& Lee, Wen-Yuan& Chen, Kuen-Bao& Chan, Yueh-Chiu& Chen, Calvin Yu-Chian. 2014. Investigation of Potent Lead for Acquired Immunodeficiency Syndrome from Traditional Chinese Medicine. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-454383
Modern Language Association (MLA)
Hung, Tzu-Chieh…[et al.]. Investigation of Potent Lead for Acquired Immunodeficiency Syndrome from Traditional Chinese Medicine. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-454383
American Medical Association (AMA)
Hung, Tzu-Chieh& Lee, Wen-Yuan& Chen, Kuen-Bao& Chan, Yueh-Chiu& Chen, Calvin Yu-Chian. Investigation of Potent Lead for Acquired Immunodeficiency Syndrome from Traditional Chinese Medicine. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-454383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454383