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Candida albicans versus Candida dubliniensis : Why Is C. albicans More Pathogenic?
Joint Authors
Coleman, David C.
Moran, Gary P.
Sullivan, Derek J.
Source
International Journal of Microbiology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Candida albicans and Candida dubliniensis are highly related pathogenic yeast species.
However, C.
albicans is far more prevalent in human infection and has been shown to be more pathogenic in a wide range of infection models.
Comparison of the genomes of the two species has revealed that they are very similar although there are some significant differences, largely due to the expansion of virulence-related gene families (e.g., ALS and SAP) in C.
albicans, and increased levels of pseudogenisation in C.
dubliniensis.
Comparative global gene expression analyses have also been used to investigate differences in the ability of the two species to tolerate environmental stress and to produce hyphae, two traits that are likely to play a role in the lower virulence of C.
dubliniensis.
Taken together, these data suggest that C.
dubliniensis is in the process of undergoing reductive evolution and may have become adapted for growth in a specialized anatomic niche.
American Psychological Association (APA)
Moran, Gary P.& Coleman, David C.& Sullivan, Derek J.. 2011. Candida albicans versus Candida dubliniensis : Why Is C. albicans More Pathogenic?. International Journal of Microbiology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-454386
Modern Language Association (MLA)
Moran, Gary P.…[et al.]. Candida albicans versus Candida dubliniensis : Why Is C. albicans More Pathogenic?. International Journal of Microbiology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-454386
American Medical Association (AMA)
Moran, Gary P.& Coleman, David C.& Sullivan, Derek J.. Candida albicans versus Candida dubliniensis : Why Is C. albicans More Pathogenic?. International Journal of Microbiology. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-454386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454386