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Discovery of Endothelium and Mesenchymal Properties of Primo Vessels in the Mesentery
Joint Authors
Zhendong, Su
Ryu, Yeon Hee
Ping, An
Hesheng, Luo
Yaling, Liu
Bae, Kyoung-Hee
Shiyun, Tan
Soh, Kwang-Sup
Kim, Sungchul
Jingxing, Dai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Recent evidences demonstrated that endothelial-to-mesenchymal transition (EndMT) has a crucial role in cancer and is recognized as a unique source of cancer-associated fibroblasts (CAFs).
Primo vascular system (PVS) is a new circulatory system which may play an important role in cancer metastasis and regeneration.
In the current study, we applied previously established time-saving method to identify primo vessels and further investigated the immunocytochemical properties of primo vessels.
Both primo vessels and primary primo vessel cells in the mesentery expressed endothelial markers and fibroblast markers.
Double-labeling experiments demonstrated that endothelial and fibroblast markers are coexpressed in primo vessels.
In addition, under the stimulation of TGF-β1 in vitro, primary primo vessel cells differentiated into fibroblasts.
Therefore, we found that primo vessels in the mesentery had a transitional structure between endothelium and mesenchymal.
This is a new finding of EndMT in normal postnatal animals.
American Psychological Association (APA)
Ping, An& Zhendong, Su& Jingxing, Dai& Yaling, Liu& Bae, Kyoung-Hee& Shiyun, Tan…[et al.]. 2013. Discovery of Endothelium and Mesenchymal Properties of Primo Vessels in the Mesentery. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-454389
Modern Language Association (MLA)
Ping, An…[et al.]. Discovery of Endothelium and Mesenchymal Properties of Primo Vessels in the Mesentery. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-454389
American Medical Association (AMA)
Ping, An& Zhendong, Su& Jingxing, Dai& Yaling, Liu& Bae, Kyoung-Hee& Shiyun, Tan…[et al.]. Discovery of Endothelium and Mesenchymal Properties of Primo Vessels in the Mesentery. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-454389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454389