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Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats
Joint Authors
Knaapen, Ad M.
ten Cate, Hugo
Cassee, Flemming R.
Spronk, Henri M. H.
Boere, A. John F.
Leseman, Daan L. A. C.
Kooter, Ingeborg M.
Gerlofs-Nijland, Miriam E.
Frederix, Kim
Fokkens, Paul H. B.
Vreman, Hendrik J.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
This study was designed to determine the sequence of events leading to cardiopulmonary effects following acute inhalation of diesel engine exhaust in rats.
Rats were exposed for 2 h to diesel engine exhaust (1.9 mg/m3), and biological parameters related to antioxidant defense, inflammation, and procoagulation were examined after 4, 18, 24, 48, and 72 h.
This in vivo inhalation study showed a pulmonary anti-oxidant response (an increased activity of the anti-oxidant enzymes glutathione peroxidase and superoxide dismutase and an increase in heme oxygenase-1 protein, heme oxygenase activity, and uric acid) which precedes the inflammatory response (an increase in IL-6 and TNF-α).
In addition, increased plasma thrombogenicity and immediate anti-oxidant defense gene expression in aorta tissue shortly after the exposure might suggest direct translocation of diesel engine exhaust components to the vasculature but mediation by other pathways cannot be ruled out.
This study therefore shows that different stages in oxidative stress are not only affected by dose increments but are also time dependent.
American Psychological Association (APA)
Kooter, Ingeborg M.& Gerlofs-Nijland, Miriam E.& Boere, A. John F.& Leseman, Daan L. A. C.& Fokkens, Paul H. B.& Spronk, Henri M. H.…[et al.]. 2010. Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats. Journal of Toxicology،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-454401
Modern Language Association (MLA)
Kooter, Ingeborg M.…[et al.]. Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats. Journal of Toxicology No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-454401
American Medical Association (AMA)
Kooter, Ingeborg M.& Gerlofs-Nijland, Miriam E.& Boere, A. John F.& Leseman, Daan L. A. C.& Fokkens, Paul H. B.& Spronk, Henri M. H.…[et al.]. Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats. Journal of Toxicology. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-454401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454401