Intracellular and Extracellular Effects of S100B in the Cardiovascular Response to Disease
Joint Authors
Mohammadzadeh, Forough
Tsoporis, James N.
Parker, Thomas G.
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
S100B, a calcium-binding protein of the EF-hand type, exerts both intracellular and extracellular functions.
S100B is induced in the myocardium of human subjects and an experimental rat model following myocardial infarction.
Forced expression of S100B in neonatal rat myocyte cultures and high level expression of S100B in transgenic mice hearts inhibit cardiac hypertrophy and the associated phenotype but augments myocyte apoptosis following myocardial infarction.
By contrast, knocking out S100B, augments hypertrophy, decreases apoptosis and preserves cardiac function following myocardial infarction.
Expression of S100B in aortic smooth muscle cells inhibits cell proliferation and the vascular response to adrenergic stimulation.
S100B induces apoptosis by an extracellular mechanism via interaction with the receptor for advanced glycation end products and activating ERK1/2 and p53 signaling.
The intracellular and extracellular roles of S100B are attractive therapeutic targets for the treatment of both cardiac and vascular diseases.
American Psychological Association (APA)
Tsoporis, James N.& Mohammadzadeh, Forough& Parker, Thomas G.. 2010. Intracellular and Extracellular Effects of S100B in the Cardiovascular Response to Disease. Cardiovascular Psychiatry and Neurology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-454402
Modern Language Association (MLA)
Tsoporis, James N.…[et al.]. Intracellular and Extracellular Effects of S100B in the Cardiovascular Response to Disease. Cardiovascular Psychiatry and Neurology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-454402
American Medical Association (AMA)
Tsoporis, James N.& Mohammadzadeh, Forough& Parker, Thomas G.. Intracellular and Extracellular Effects of S100B in the Cardiovascular Response to Disease. Cardiovascular Psychiatry and Neurology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-454402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454402