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Short-Term Bisphosphonate Therapy Could Ameliorate Osteonecrosis : A Complication in Childhood Hematologic Malignancies
Joint Authors
Messina, C.
Calore, E.
Pillon, M.
Greggio, N. A.
Varotto, E.
Palozzo, A. C.
Talenti, E.
Zanin, A.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Osteonecrosis (ON) is a critical complication in the treatment of childhood leukemia and lymphoma.
It particularly affects survivors of acute lymphoblastic leukemia and non-Hodgkin lymphoma reflecting the cumulative exposure to glucocorticosteroid therapy.
ON is often multiarticular and bilateral, specially affecting weight-bearing joints.
A conventional approach suggests a surgical intervention even if pharmacological options have also recently been investigated.
We reported two cases of long time steroid-treated patients who underwent Bone Marrow Transplantation (BMT) for hematological disease.
Both patients developed femoral head osteonecrosis (ON) that was diagnosed by magnetic resonance imaging (MRI) and the ON was also accompanied with pain and a limp.
Despite of the conventional strategies of therapy, we successfully started a short-term treatment with bisphosphonates in order to decrease the pain and the risk of fracture.
American Psychological Association (APA)
Greggio, N. A.& Pillon, M.& Varotto, E.& Zanin, A.& Talenti, E.& Palozzo, A. C.…[et al.]. 2010. Short-Term Bisphosphonate Therapy Could Ameliorate Osteonecrosis : A Complication in Childhood Hematologic Malignancies. Case Reports in Medicine،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-454411
Modern Language Association (MLA)
Greggio, N. A.…[et al.]. Short-Term Bisphosphonate Therapy Could Ameliorate Osteonecrosis : A Complication in Childhood Hematologic Malignancies. Case Reports in Medicine No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-454411
American Medical Association (AMA)
Greggio, N. A.& Pillon, M.& Varotto, E.& Zanin, A.& Talenti, E.& Palozzo, A. C.…[et al.]. Short-Term Bisphosphonate Therapy Could Ameliorate Osteonecrosis : A Complication in Childhood Hematologic Malignancies. Case Reports in Medicine. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-454411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454411