Optimal Treatment Strategy for a Tumor Model under Immune Suppression
Joint Authors
Jung, Il Hyo
Cho, Giphil
Kim, Kwang Su
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
We propose a mathematical model describing tumor-immune interactions under immune suppression.
These days evidences indicate that the immune suppression related to cancer contributes to its progression.
The mathematical model for tumor-immune interactions would provide a new methodology for more sophisticated treatment options of cancer.
To do this we have developed a system of 11 ordinary differential equations including the movement, interaction, and activation of NK cells, CD8+T-cells, CD4+T cells, regulatory T cells, and dendritic cells under the presence of tumor and cytokines and the immune interactions.
In addition, we apply two control therapies, immunotherapy and chemotherapy to the model in order to control growth of tumor.
Using optimal control theory and numerical simulations, we obtain appropriate treatment strategies according to the ratio of the cost for two therapies, which suggest an optimal timing of each administration for the two types of models, without and with immunosuppressive effects.
These results mean that the immune suppression can have an influence on treatment strategies for cancer.
American Psychological Association (APA)
Kim, Kwang Su& Cho, Giphil& Jung, Il Hyo. 2014. Optimal Treatment Strategy for a Tumor Model under Immune Suppression. Computational and Mathematical Methods in Medicine،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-454432
Modern Language Association (MLA)
Kim, Kwang Su…[et al.]. Optimal Treatment Strategy for a Tumor Model under Immune Suppression. Computational and Mathematical Methods in Medicine No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-454432
American Medical Association (AMA)
Kim, Kwang Su& Cho, Giphil& Jung, Il Hyo. Optimal Treatment Strategy for a Tumor Model under Immune Suppression. Computational and Mathematical Methods in Medicine. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-454432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454432