A Possible Role of HMGB1 in DNA Demethylation in CD4+ T Cells from Patients with Systemic Lupus Erythematosus
Joint Authors
Liang, Gongping
Huang, Chenghui
Xiao, Rong
Lu, Qianjin
Yung, Susan
Chan, Tak Mao
Zhao, Ming
Li, Yaping
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aberrant activity of CD4+ T cells in patients with systemic lupus erythematosus (SLE) is associated with DNA hypomethylation of the regulatory regions in CD11a and CD70 genes.
Our previous studies demonstrated that Gadd45a contributes to the development of SLE by promoting DNA demethylation in CD4+ T cells.
In this study, we identified proteins that bind to Gadd45a in CD4+ T cells during SLE flare by using the method of co-immunoprecipitation and mass spectrometry, High mobility group box protein 1 (HMGB1) is one of identified proteins.
Furthermore, gene and protein expression of HMGB1 was significantly increased in SLE CD4+ T cells compared to controls, and HMGB1 mRNA was correlated with CD11a and CD70 mRNA.
A significant, positive correlation was found between HMGB1 mRNA and SLEDAI for SLE patients.
Our data demonstrate that HMGB1 binds to Gadd45a and may be involved in DNA demethylation in CD4+ T cells during lupus flare.
American Psychological Association (APA)
Li, Yaping& Huang, Chenghui& Zhao, Ming& Liang, Gongping& Xiao, Rong& Yung, Susan…[et al.]. 2013. A Possible Role of HMGB1 in DNA Demethylation in CD4+ T Cells from Patients with Systemic Lupus Erythematosus. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-454434
Modern Language Association (MLA)
Li, Yaping…[et al.]. A Possible Role of HMGB1 in DNA Demethylation in CD4+ T Cells from Patients with Systemic Lupus Erythematosus. Clinical and Developmental Immunology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-454434
American Medical Association (AMA)
Li, Yaping& Huang, Chenghui& Zhao, Ming& Liang, Gongping& Xiao, Rong& Yung, Susan…[et al.]. A Possible Role of HMGB1 in DNA Demethylation in CD4+ T Cells from Patients with Systemic Lupus Erythematosus. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-454434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454434
