Development of Quantitative Structure-Property Relationship Models for Self-Emulsifying Drug Delivery System of 2-Aryl Propionic Acid NSAIDs
Joint Authors
He, Rui
Yang, Sheng-Yong
Yin, Zong-Ning
Tao, Wan-Jun
Li, Chen-Wen
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
We developed the quantative structure-property relationships (QSPRs) models to correlate the molecular structures of surfactant, cosurfactant, oil, and drug with the solubility of poorly water-soluble 2-aryl propionic acid nonsteroidal anti-inflammatory drugs (2-APA-NSAIDs) in self-emulsifying drug delivery systems (SEDDSs).
The compositions were encoded with electronic, geometrical, topological, and quantum chemical descriptors.
To obtain reliable predictions, we used multiple linear regression (MLR) and artificial neural network (ANN) methods for model development.
The obtained equations were validated using a test set of 42 formulations and showed a great predictive power, and linear models were found to be better than nonlinear ones.
The obtained QSPR models would greatly facilitate fast screening for the optimal formulations of SEDDS at the early stage of drug development and minimize experimental effort.
American Psychological Association (APA)
Li, Chen-Wen& Yang, Sheng-Yong& He, Rui& Tao, Wan-Jun& Yin, Zong-Ning. 2011. Development of Quantitative Structure-Property Relationship Models for Self-Emulsifying Drug Delivery System of 2-Aryl Propionic Acid NSAIDs. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-454438
Modern Language Association (MLA)
Li, Chen-Wen…[et al.]. Development of Quantitative Structure-Property Relationship Models for Self-Emulsifying Drug Delivery System of 2-Aryl Propionic Acid NSAIDs. Journal of Nanomaterials No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-454438
American Medical Association (AMA)
Li, Chen-Wen& Yang, Sheng-Yong& He, Rui& Tao, Wan-Jun& Yin, Zong-Ning. Development of Quantitative Structure-Property Relationship Models for Self-Emulsifying Drug Delivery System of 2-Aryl Propionic Acid NSAIDs. Journal of Nanomaterials. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-454438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454438