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Synthesis, Spectroscopic, Anticancer, and Antimicrobial Properties of Some Metal(II) Complexes of (Substituted) Nitrophenol Schiff Base
Joint Authors
Osowole, Aderoju Amoke
Ott, Ingo
Ogunlana, Oladunni M.
Source
International Journal of Inorganic Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The Schiff base, 2-[(2,3-dihydro-1H-inden-4-ylimino)methyl]-5-nitrophenol coordinates to Mn(II), Cu(II), Zn(II), and Pd(II) ions through the phenolic O and imine N atoms.
The complexes are characterized by physicochemical and spectroscopic methods.
The metal complexes formed as [ML2]xH2O with exception of the Cu(II) complex which is anhydrous.
Spectroscopic data corroborate the adoption of a four-coordinate, tetrahedral geometry for the Mn(II), and Zn(II) complexes, and a four-coordinate, square planar geometry for the Cu(II) and Pd(II) complexes.
None is an electrolyte in DMSO.
The in vitro anticancer activities of the metal free ligand, Cu(II), Zn(II), and Pd(II) complexes against MCF-7 (human breast adenocarcinoma) and HT-29 (colon carcinoma) cells reveal that the Pd(II) complex has the best cytotoxic activity against MCF-7 cells with an IC50 of 5.94 μM, which is within the same order of activity as cisplatin.
Furthermore, the ligand and the Zn(II) complex exhibit broad-spectrum activity against two gram-positive bacteria, three gram-negative bacteria, and a fungus with inhibitory zones range of 10.0–20.0 and 10.0–17.0 mm, respectively.
American Psychological Association (APA)
Osowole, Aderoju Amoke& Ott, Ingo& Ogunlana, Oladunni M.. 2012. Synthesis, Spectroscopic, Anticancer, and Antimicrobial Properties of Some Metal(II) Complexes of (Substituted) Nitrophenol Schiff Base. International Journal of Inorganic Chemistry،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-454454
Modern Language Association (MLA)
Osowole, Aderoju Amoke…[et al.]. Synthesis, Spectroscopic, Anticancer, and Antimicrobial Properties of Some Metal(II) Complexes of (Substituted) Nitrophenol Schiff Base. International Journal of Inorganic Chemistry No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-454454
American Medical Association (AMA)
Osowole, Aderoju Amoke& Ott, Ingo& Ogunlana, Oladunni M.. Synthesis, Spectroscopic, Anticancer, and Antimicrobial Properties of Some Metal(II) Complexes of (Substituted) Nitrophenol Schiff Base. International Journal of Inorganic Chemistry. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-454454
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454454