Family History of Autoimmune Disease in Patients with Aicardi-Goutières Syndrome
Joint Authors
Schmidt, Johanna L.
Vanderver, Adeline
Fazzi, Elisa
Vento, Jodie M.
Orcesi, Simona
Gordish-Dressman, Heather
Olivieri, Ivana
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
The purpose of this study was to explore anecdotal evidence for an increase in the prevalence of autoimmune diseases in family members of patients with Aicardi-Goutières syndrome (AGS).
Methods.
Pedigrees of patients and controls were analyzed using chi-square and logistic regression to assess differences in reports of autoimmune disease among family members of cases and controls.
Data was collected at Children's National Medical Center in Washington, DC, USA and at the International Aicardi-Goutières Syndrome Association Scientific Headquarters, C.
Mondino National Institute of Neurology in Pavia, Italy.
Results.
The number of individuals with reported autoimmune disease is significantly related to having a family member with AGS (χ2=6.25, P=0.01); 10% (35/320) of relatives of patients with AGS had a reported autoimmune disease diagnosis compared to 5% (18/344) of relatives of controls.
There was a greater percent of maternal relatives of patients with AGS reporting autoimmune disease (14.6%), compared to controls (6.8%), with the association being statistically significant.
The association was not significant for paternal relatives.
Conclusion.
The prevalence of autoimmune disease in relatives of children with AGS is significantly increased compared to controls.
More research is needed to better understand this association.
American Psychological Association (APA)
Schmidt, Johanna L.& Olivieri, Ivana& Vento, Jodie M.& Fazzi, Elisa& Gordish-Dressman, Heather& Orcesi, Simona…[et al.]. 2012. Family History of Autoimmune Disease in Patients with Aicardi-Goutières Syndrome. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-454472
Modern Language Association (MLA)
Schmidt, Johanna L.…[et al.]. Family History of Autoimmune Disease in Patients with Aicardi-Goutières Syndrome. Clinical and Developmental Immunology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-454472
American Medical Association (AMA)
Schmidt, Johanna L.& Olivieri, Ivana& Vento, Jodie M.& Fazzi, Elisa& Gordish-Dressman, Heather& Orcesi, Simona…[et al.]. Family History of Autoimmune Disease in Patients with Aicardi-Goutières Syndrome. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-454472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454472