Archaeal Genome Guardians Give Insights into Eukaryotic DNA Replication and Damage Response Proteins
Joint Authors
Pratt, Ashley J.
Shin, David S.
Tainer, John A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-24, 24 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-20
Country of Publication
Egypt
No. of Pages
24
Main Subjects
Abstract EN
As the third domain of life, archaea, like the eukarya and bacteria, must have robust DNA replication and repair complexes to ensure genome fidelity.
Archaea moreover display a breadth of unique habitats and characteristics, and structural biologists increasingly appreciate these features.
As archaea include extremophiles that can withstand diverse environmental stresses, they provide fundamental systems for understanding enzymes and pathways critical to genome integrity and stress responses.
Such archaeal extremophiles provide critical data on the periodic table for life as well as on the biochemical, geochemical, and physical limitations to adaptive strategies allowing organisms to thrive under environmental stress relevant to determining the boundaries for life as we know it.
Specifically, archaeal enzyme structures have informed the architecture and mechanisms of key DNA repair proteins and complexes.
With added abilities to temperature-trap flexible complexes and reveal core domains of transient and dynamic complexes, these structures provide insights into mechanisms of maintaining genome integrity despite extreme environmental stress.
The DNA damage response protein structures noted in this review therefore inform the basis for genome integrity in the face of environmental stress, with implications for all domains of life as well as for biomanufacturing, astrobiology, and medicine.
American Psychological Association (APA)
Shin, David S.& Pratt, Ashley J.& Tainer, John A.. 2014. Archaeal Genome Guardians Give Insights into Eukaryotic DNA Replication and Damage Response Proteins. Archaea،Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-454474
Modern Language Association (MLA)
Shin, David S.…[et al.]. Archaeal Genome Guardians Give Insights into Eukaryotic DNA Replication and Damage Response Proteins. Archaea No. 2014 (2014), pp.1-24.
https://search.emarefa.net/detail/BIM-454474
American Medical Association (AMA)
Shin, David S.& Pratt, Ashley J.& Tainer, John A.. Archaeal Genome Guardians Give Insights into Eukaryotic DNA Replication and Damage Response Proteins. Archaea. 2014. Vol. 2014, no. 2014, pp.1-24.
https://search.emarefa.net/detail/BIM-454474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454474