Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood
Joint Authors
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
While most circulating angiotensinogen (AGT) is synthesized in the liver, the kidneys also produce AGT.
Recently, we reported that urinary AGT is mainly originated from AGT.
Using newly developed human AGT ELISA, we measured urinary AGT levels in chronic glomerulonephritis (GN) patients and patients with type 1 diabetes in childhood.
Urinary AGT level was positively correlated with diastolic blood pressure, urinary albumin, urinary protein levels, and urinary occult blood in chronic GN patients.
Furthermore, urinary AGT level was significantly increased in chronic GN patients not treated with renin-angiotensin system (RAS) blockers compared with control subjects.
Importantly, patients treated with RAS blockers had a marked attenuation of this increase.
Also, urinary AGT level was significantly higher in patients with diabetic nephropathy in the premicroalbuminuric phase than in control subjects.
These results suggest that urinary AGT reflects intrarenal RAS status in chronic GN and may be an early marker of diabetic nephropathy.
American Psychological Association (APA)
Urushihara, Maki& Kagami, Shoji. 2011. Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454484
Modern Language Association (MLA)
Urushihara, Maki& Kagami, Shoji. Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood. International Journal of Nephrology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-454484
American Medical Association (AMA)
Urushihara, Maki& Kagami, Shoji. Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454484