Thymic Epithelial Cell Development and Its Dysfunction in Human Diseases
Joint Authors
Li, Hongran
Luo, Haiying
Zhao, Yong
Sun, Lina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Thymic epithelial cells (TECs) are the key components in thymic microenvironment for T cells development.
TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor and undergo a stepwise development controlled by multiple levels of signals to be functionally mature for supporting thymocyte development.
Tumor necrosis factor receptor (TNFR) family members including the receptor activator for NFκB (RANK), CD40, and lymphotoxin β receptor (LTβR) cooperatively control the thymic medullary microenvironment and self-tolerance establishment.
In addition, fibroblast growth factors (FGFs), Wnt, and Notch signals are essential for establishment of functional thymic microenvironment.
Transcription factors Foxn1 and autoimmune regulator (Aire) are powerful modulators of TEC development, differentiation, and self-tolerance.
Dysfunction in thymic microenvironment including defects of TEC and thymocyte development would cause physiological disorders such as tumor, infectious diseases, and autoimmune diseases.
In the present review, we will summarize our current understanding on TEC development and the underlying molecular signals pathways and the involvement of thymus dysfunction in human diseases.
American Psychological Association (APA)
Sun, Lina& Li, Hongran& Luo, Haiying& Zhao, Yong. 2014. Thymic Epithelial Cell Development and Its Dysfunction in Human Diseases. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-454498
Modern Language Association (MLA)
Sun, Lina…[et al.]. Thymic Epithelial Cell Development and Its Dysfunction in Human Diseases. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-454498
American Medical Association (AMA)
Sun, Lina& Li, Hongran& Luo, Haiying& Zhao, Yong. Thymic Epithelial Cell Development and Its Dysfunction in Human Diseases. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-454498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454498