Histopathologic Overlap between Fibrosing Mediastinitis and IgG4-Related Disease
Joint Authors
Specks, Ulrich
Peikert, Tobias
Aubry, Marie Christine
Sekiguchi, Hiroshi
Yi, Eunhee S.
Ryu, Jay H.
Shrestha, Bijayee
Smyrk, Thomas C.
Colby, Thomas V.
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Fibrosing mediastinitis (FM) and IgG4-related disease (IgG4-RD) are two fibroinflammatory disorders with potentially overlapping clinical and radiological features.
In this paper, we looked for histopathologic features of IgG4-RD and enumerated infiltrating IgG4-positive plasma cells within mediastinal tissue biopsies from FM patients.
We identified 15 consecutive FM surgical mediastinal tissue biopsies between 1985 and 2006.
All patients satisfied the clinical and radiological diagnostic criteria for FM.
All patients had either serological or radiological evidence of prior histoplasmosis or granulomatous disease, respectively.
Formalin-fixed paraffin-embedded tissue sections of all patients were stained for H&E, IgG, and IgG4.
Three samples met the predefined diagnostic criteria for IgG4-RD.
In addition, characteristic histopathologic changes of IgG4-RD in the absence of diagnostic numbers of tissue infiltrating IgG4-positive plasma cells were seen in a number of additional cases (storiform cell-rich fibrosis in 11 cases, lymphoplasmacytic infiltrate in 7 cases, and obliterative phlebitis/arteritis in 2 cases).
We conclude that up to one-third of histoplasmosis or granulomatous-disease-associated FM cases demonstrate histopathological features of IgG4-RD spectrum.
Whether these changes occur as the host immune response against Histoplasma or represent a manifestation of IgG4-RD remains to be determined.
Studies to prospectively identify these cases and evaluate their therapeutic responses to glucocorticoids and/or other immunosuppressive agents such as rituximab are warranted.
American Psychological Association (APA)
Peikert, Tobias& Shrestha, Bijayee& Aubry, Marie Christine& Colby, Thomas V.& Ryu, Jay H.& Sekiguchi, Hiroshi…[et al.]. 2012. Histopathologic Overlap between Fibrosing Mediastinitis and IgG4-Related Disease. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-454514
Modern Language Association (MLA)
Peikert, Tobias…[et al.]. Histopathologic Overlap between Fibrosing Mediastinitis and IgG4-Related Disease. International Journal of Rheumatology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-454514
American Medical Association (AMA)
Peikert, Tobias& Shrestha, Bijayee& Aubry, Marie Christine& Colby, Thomas V.& Ryu, Jay H.& Sekiguchi, Hiroshi…[et al.]. Histopathologic Overlap between Fibrosing Mediastinitis and IgG4-Related Disease. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-454514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454514