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The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is a prototype autoimmune disease that affects multiorgan systems.
Lupus nephritis is one of the most severe manifestations of SLE whereby immune-mediated inflammation can lead to permanent damage within the glomerular, tubulo-interstitial, and vascular compartments of the kidney, resulting in acute or chronic renal failure.
The mechanisms that regulate host inflammatory responses and tissue injury are incompletely understood.
Accumulating evidence suggests that hyaluronan and its interaction with its cell surface receptor CD44 plays an important role in mediating pathogenic mechanisms in SLE.
This paper discusses the putative mechanisms through which hyaluronan and CD44 contribute to the pathogenesis of SLE, with particular emphasis on lupus nephritis.
American Psychological Association (APA)
Yung, Susan& Chan, Tak Mao. 2012. The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-454528
Modern Language Association (MLA)
Yung, Susan& Chan, Tak Mao. The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis. Autoimmune Diseases No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-454528
American Medical Association (AMA)
Yung, Susan& Chan, Tak Mao. The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-454528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454528