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Human Motor Neuron Progenitor Transplantation Leads to Endogenous Neuronal Sparing in 3 Models of Motor Neuron Loss
Joint Authors
Rossi, Sharyn L.
Keirstead, Hans S.
Siegenthaler, Monica M.
Nistor, Gabriel
Robles, Rockelle
Frame, Jennifer
Wyatt, Tanya J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Motor neuron loss is characteristic of many neurodegenerative disorders and results in rapid loss of muscle control, paralysis, and eventual death in severe cases.
In order to investigate the neurotrophic effects of a motor neuron lineage graft, we transplanted human embryonic stem cell-derived motor neuron progenitors (hMNPs) and examined their histopathological effect in three animal models of motor neuron loss.
Specifically, we transplanted hMNPs into rodent models of SMA (Δ7SMN), ALS (SOD1 G93A), and spinal cord injury (SCI).
The transplanted cells survived and differentiated in all models.
In addition, we have also found that hMNPs secrete physiologically active growth factors in vivo, including NGF and NT-3, which significantly enhanced the number of spared endogenous neurons in all three animal models.
The ability to maintain dying motor neurons by delivering motor neuron-specific neurotrophic support represents a powerful treatment strategy for diseases characterized by motor neuron loss.
American Psychological Association (APA)
Wyatt, Tanya J.& Rossi, Sharyn L.& Siegenthaler, Monica M.& Frame, Jennifer& Robles, Rockelle& Nistor, Gabriel…[et al.]. 2011. Human Motor Neuron Progenitor Transplantation Leads to Endogenous Neuronal Sparing in 3 Models of Motor Neuron Loss. Stem Cells International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-454531
Modern Language Association (MLA)
Wyatt, Tanya J.…[et al.]. Human Motor Neuron Progenitor Transplantation Leads to Endogenous Neuronal Sparing in 3 Models of Motor Neuron Loss. Stem Cells International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-454531
American Medical Association (AMA)
Wyatt, Tanya J.& Rossi, Sharyn L.& Siegenthaler, Monica M.& Frame, Jennifer& Robles, Rockelle& Nistor, Gabriel…[et al.]. Human Motor Neuron Progenitor Transplantation Leads to Endogenous Neuronal Sparing in 3 Models of Motor Neuron Loss. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-454531
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454531