CCN1 Induces β-Catenin Translocation in Esophageal Squamous Cell Carcinoma through Integrin α11
Joint Authors
Modak, Cristina
Wu, Sing-Yung
Chai, Jianyuan
Jamal, M. Mazen
Ouyang, Yi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
Nuclear translocation of β-catenin is common in many cancers including esophageal squamous cell carcinoma (ESCC).
As a mediator of Wnt signaling pathway, nuclear β-catenin can activate many growth-related genes including CCN1, which in turn can induce β-catenin translocation.
CCN1, a matricellular protein, signals through various integrin receptors in a cell-dependent manner to regulate cell adhesion, proliferation, and survival.
Its elevation has been reported in ESCC as well as other esophageal abnormalities such as Barrett’s esophagus.
The aim of this study is to examine the relationship between CCN1 and β-catenin in ESCC.
Methods and Results.
The expression and correlation between CCN1 and β-catenin in ESCC tissue were examined through immunohistochemistry and further analyzed in both normal esophageal epithelial cells and ESCC cells through microarray, functional blocking and in situ protein ligation.
We found that nuclear translocation of β-catenin in ESCC cells required high level of CCN1 as knockdown of CCN1 in ESCC cells reduced β-catenin expression and translocation.
Furthermore, we found that integrin α11 was highly expressed in ESCC tumor tissue and functional blocking integrin α11 diminished CCN1-induced β-catenin elevation and translocation.
Conclusions.
Integrin α11 mediated the effect of CCN1 on β-catenin in esophageal epithelial cells.
American Psychological Association (APA)
Chai, Jianyuan& Modak, Cristina& Ouyang, Yi& Wu, Sing-Yung& Jamal, M. Mazen. 2012. CCN1 Induces β-Catenin Translocation in Esophageal Squamous Cell Carcinoma through Integrin α11. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-454532
Modern Language Association (MLA)
Chai, Jianyuan…[et al.]. CCN1 Induces β-Catenin Translocation in Esophageal Squamous Cell Carcinoma through Integrin α11. ISRN Gastroenterology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-454532
American Medical Association (AMA)
Chai, Jianyuan& Modak, Cristina& Ouyang, Yi& Wu, Sing-Yung& Jamal, M. Mazen. CCN1 Induces β-Catenin Translocation in Esophageal Squamous Cell Carcinoma through Integrin α11. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-454532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454532