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Cortex Moutan Induces Bladder Cancer Cell Death via Apoptosis and Retards Tumor Growth in Mouse Bladders
Joint Authors
Hsu, Cheng-Da
Chiang, Su-Yin
Chen, Yueh-Sheng
Li, Yi-Zhen
Liu, Yi-Wen
Lee, Ying-Ray
Lin, Mei-Yi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cortex Moutan is the root bark of Paeonia suffruticosa Andr.
It is the herbal medicine widely used in Traditional Chinese Medicine for the treatment of blood-heat and blood-stasis syndrome.
Furthermore, it has been reported that Cortex Moutan has anticancer effect.
In this study, the Cortex Moutan extract was evaluated in bladder cancer therapy in vitro and in vivo.
Cortex Moutan extract reduces cell viability with IC50 between 1~2 mg/ml in bladder cancer cells, and it has lower cytotoxicity in normal urotheliums.
It arrests cells in G1 and S phase and causes phosphatidylserine expression in the outside of cell membrane.
It induces caspase-8 and caspase-3 activation and poly(ADP-ribose) polymerase degradation.
The pan caspase inhibitor z-VAD-fmk reverses Cortex Moutan-induced cell death.
Cortex Moutan also inhibits cell invasion activity in 5637 cells.
In mouse orthotopic bladder cancer model, intravesical application of Cortex Moutan decreases the bladder tumor size without altering the blood biochemical parameters.
In summary, these results demonstrate the antiproliferation and anti-invasion properties of Cortex Moutan in bladder cancer cells and its antibladder tumor effect in vivo.
Cortex Moutan may provide an alternative therapeutic strategy for the intravesical therapy of superficial bladder cancer.
American Psychological Association (APA)
Lin, Mei-Yi& Lee, Ying-Ray& Chiang, Su-Yin& Li, Yi-Zhen& Chen, Yueh-Sheng& Hsu, Cheng-Da…[et al.]. 2013. Cortex Moutan Induces Bladder Cancer Cell Death via Apoptosis and Retards Tumor Growth in Mouse Bladders. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-454536
Modern Language Association (MLA)
Lin, Mei-Yi…[et al.]. Cortex Moutan Induces Bladder Cancer Cell Death via Apoptosis and Retards Tumor Growth in Mouse Bladders. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-454536
American Medical Association (AMA)
Lin, Mei-Yi& Lee, Ying-Ray& Chiang, Su-Yin& Li, Yi-Zhen& Chen, Yueh-Sheng& Hsu, Cheng-Da…[et al.]. Cortex Moutan Induces Bladder Cancer Cell Death via Apoptosis and Retards Tumor Growth in Mouse Bladders. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-454536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454536