Bone Marrow Stem Cell Derived Paracrine Factors for Regenerative Medicine : Current Perspectives and Therapeutic Potential

Abstract EN

During the past several years, there has been intense research in the field of bone marrow-derived stem cell (BMSC) therapy to facilitate its translation into clinical setting.

Although a lot has been accomplished, plenty of challenges lie ahead.

Furthermore, there is a growing body of evidence showing that administration of BMSC-derived conditioned media (BMSC-CM) can recapitulate the beneficial effects observed after stem cell therapy.

BMSCs produce a wide range of cytokines and chemokines that have, until now, shown extensive therapeutic potential.

These paracrine mechanisms could be as diverse as stimulating receptor-mediated survival pathways, inducing stem cell homing and differentiation or regulating the anti-inflammatory effects in wounded areas.

The current review reflects the rapid shift of interest from BMSC to BMSC-CM to alleviate many logistical and technical issues regarding cell therapy and evaluates its future potential as an effective regenerative therapy.