PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells
Joint Authors
Chandra, Joya
Gonzales, Carolina
Gao, Shan
Miller, Claudia P.
Balasubramanian, Sriram
Sirisawad, Mint
Rivera-Del Valle, Nilsa
Wheler, Jennifer
Fulbright, Joy
Steggerda, Susanne
Source
International Journal of Cell Biology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Histone deacetylase inhibitors (HDACi) have become a promising new avenue for cancer therapy, and many are currently in Phase I/II clinical trials for various tumor types.
In the present study, we show that apoptosis induction and histone alterations by PCI-24781, a novel hydroxamic acid-based HDAC inhibitor, require caspase-8 and the adaptor molecule, Fas-associated death domain (FADD), in acute leukemia cells.
PCI-24781 treatment also causes an increase in superoxide levels, which has been reported for other HDACi.
However, an antioxidant does not reverse histone alterations caused by PCI-24781, indicating that ROS generation is likely downstream of the effects that PCI-24781 exerts on histone H3.
Taken together, these results provide insight into the mechanism of apoptosis induction by PCI-24781 in leukemia by highlighting the roles of caspase-8, FADD and increased superoxide levels.
American Psychological Association (APA)
Rivera-Del Valle, Nilsa& Gao, Shan& Miller, Claudia P.& Fulbright, Joy& Gonzales, Carolina& Sirisawad, Mint…[et al.]. 2010. PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells. International Journal of Cell Biology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-454552
Modern Language Association (MLA)
Rivera-Del Valle, Nilsa…[et al.]. PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells. International Journal of Cell Biology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-454552
American Medical Association (AMA)
Rivera-Del Valle, Nilsa& Gao, Shan& Miller, Claudia P.& Fulbright, Joy& Gonzales, Carolina& Sirisawad, Mint…[et al.]. PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells. International Journal of Cell Biology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-454552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454552