The MRLlpr Mouse Strain as a Model for Neuropsychiatric Systemic Lupus Erythematosus
Joint Authors
Gulinello, Maria
Putterman, Chaim
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
To date, CNS disease and neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) have been understudied compared to end-organ failure and peripheral pathology.
In this review, we focus on a specific mouse model of lupus and the ways in which this model reflects some of the most common manifestations and potential mechanisms of human NP-SLE.
The mouse MRL lymphoproliferation strain (a.k.a.
MRL/lpr) spontaneously develops the hallmark serological markers and peripheral pathologies typifying lupus in addition to displaying the cognitive and affective dysfunction characteristic of NP-SLE, which may be among the earliest symptoms of lupus.
We suggest that although NP-SLE may share common mechanisms with peripheral organ pathology in lupus, especially in the latter stages of the disease, the immunologically privileged nature of the CNS indicates that early manifestations of particularly mood disorders maybe derived from some unique mechanisms.
These include altered cytokine profiles that can activate astrocytes, microglia, and alter neuronal function before dysregulation of the blood-brain barrier and development of clinical autoantibody titres.
American Psychological Association (APA)
Gulinello, Maria& Putterman, Chaim. 2011. The MRLlpr Mouse Strain as a Model for Neuropsychiatric Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-454562
Modern Language Association (MLA)
Gulinello, Maria& Putterman, Chaim. The MRLlpr Mouse Strain as a Model for Neuropsychiatric Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-454562
American Medical Association (AMA)
Gulinello, Maria& Putterman, Chaim. The MRLlpr Mouse Strain as a Model for Neuropsychiatric Systemic Lupus Erythematosus. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-454562
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454562