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Association of TNFAIP3 Polymorphism with Susceptibility to Systemic Lupus Erythematosus in a Japanese Population
Joint Authors
Goto, Daisuke
Takasaki, Yoshinari
Matsumoto, Isao
Sumida, Takayuki
Ito, Satoshi
Tsuchiya, Naoyuki
Kawasaki, Aya
Hayashi, Taichi
Ito, Ikue
Hashimoto, Hiroshi
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Recent genome-wide association studies demonstrated association of single nucleotide polymorphisms (SNPs) in the TNFAIP3 region at 6q23 with systemic lupus erythematosus (SLE) in European-American populations.
In this study, we investigated whether SNPs in the TNFAIP3 region are associated with SLE also in a Japanese population.
A case-control association study was performed on the SNPs rs13192841, rs2230926, and rs6922466 in 318 Japanese SLE patients and 444 healthy controls.
Association of rs2230926 G allele with SLE was replicated in Japanese (allelic association P=.033, odds ratio [OR] 1.47, recessive model P=.023, OR 8.52).
The association was preferentially observed in the SLE patients with nephritis.
When the TNFAIP3 mRNA levels of the HapMap samples were examined using GENEVAR database, the presence of TNFAIP3 rs2230926 G allele was associated with lower mRNA expression of TNFAIP3 (P=.013).
These results indicated that TNFAIP3 is a susceptibility gene to SLE both in the Caucasian and Asian populations.
American Psychological Association (APA)
Kawasaki, Aya& Ito, Ikue& Ito, Satoshi& Hayashi, Taichi& Goto, Daisuke& Matsumoto, Isao…[et al.]. 2010. Association of TNFAIP3 Polymorphism with Susceptibility to Systemic Lupus Erythematosus in a Japanese Population. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-454569
Modern Language Association (MLA)
Kawasaki, Aya…[et al.]. Association of TNFAIP3 Polymorphism with Susceptibility to Systemic Lupus Erythematosus in a Japanese Population. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-454569
American Medical Association (AMA)
Kawasaki, Aya& Ito, Ikue& Ito, Satoshi& Hayashi, Taichi& Goto, Daisuke& Matsumoto, Isao…[et al.]. Association of TNFAIP3 Polymorphism with Susceptibility to Systemic Lupus Erythematosus in a Japanese Population. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-454569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454569