Enhanced Osteogenicity of Bioactive Composites with Biomimetic Treatment
Joint Authors
Seppälä, Jukka V.
Närhi, Timo O.
Tirri, Teemu
Malin, Minna
Meretoja, Ville V.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
This study aimed to explore if initiation of biomimetic apatite nucleation can be used to enhance osteoblast response to biodegradable tissue regeneration composite membranes.
Materials and Methods.
Bioactive thermoplastic composites consisting of poly(ε-caprolactone/DL-lactide) and bioactive glass (BAG) were prepared at different stages of biomimetic calcium phosphate deposition by immersion in simulated body fluid (SBF).
The modulation of the BAG dissolution and the osteogenic response of rat mesenchymal stem cells (MSCs) were analyzed.
Results.
SBF treatment resulted in a gradual calcium phosphate deposition on the composites and decreased BAG reactivity in the subsequent cell cultures.
Untreated composites and composites covered by thick calcium phosphate layer (14 days in SBF) expedited MSC mineralization in comparison to neat polymers without BAG, whereas other osteogenic markers—alkaline phosphatase activity, bone sialoprotein, and osteocalcin expression—were initially decreased.
In contrast, surfaces with only small calcium phosphate aggregates (five days in SBF) had similar early response than neat polymers but still demonstrated enhanced mineralization.
Conclusion.
A short biomimetic treatment enhances osteoblast response to bioactive composite membranes.
American Psychological Association (APA)
Meretoja, Ville V.& Tirri, Teemu& Malin, Minna& Seppälä, Jukka V.& Närhi, Timo O.. 2014. Enhanced Osteogenicity of Bioactive Composites with Biomimetic Treatment. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-454582
Modern Language Association (MLA)
Meretoja, Ville V.…[et al.]. Enhanced Osteogenicity of Bioactive Composites with Biomimetic Treatment. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-454582
American Medical Association (AMA)
Meretoja, Ville V.& Tirri, Teemu& Malin, Minna& Seppälä, Jukka V.& Närhi, Timo O.. Enhanced Osteogenicity of Bioactive Composites with Biomimetic Treatment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-454582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454582