A New Perspective on Intercalated Disc Organization : Implications for Heart Disease
Joint Authors
Source
Dermatology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Adherens junctions and desmosomes are intercellular adhesive junctions and essential for the morphogenesis, differentiation, and maintenance of tissues that are subjected to high mechanical stress, including heart and skin.
The different junction complexes are organized at the termini of the cardiomyocyte called the intercalated disc.
Disruption of adhesive integrity via mutations in genes encoding desmosomal proteins causes an inherited heart disease, arrhythmogenic right ventricular cardiomyopathy (ARVC).
Besides plakoglobin, which is shared by adherens junctions and desmosomes, other desmosomal components, desmoglein-2, desmocollin-2, plakophilin-2, and desmoplakin are also present in ultrastructurally defined fascia adherens junctions of heart muscle, but not other tissues.
This mixed-type of junctional structure is termed hybrid adhering junction or area composita.
Desmosomal plakophilin-2 directly interacts with adherens junction protein alphaT-catenin, providing a new molecular link between the cadherin-catenin complex and desmosome.
The area composita only exists in the cardiac intercalated disc of mammalian species suggesting that it evolved to strengthen mechanical coupling in the heart of higher vertebrates.
The cross-talk among different junctions and their implication in the pathogenesis of ARVC are discussed in this review.
American Psychological Association (APA)
Li, Jifen& Radice, Glenn L.. 2010. A New Perspective on Intercalated Disc Organization : Implications for Heart Disease. Dermatology Research and Practice،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-454587
Modern Language Association (MLA)
Li, Jifen& Radice, Glenn L.. A New Perspective on Intercalated Disc Organization : Implications for Heart Disease. Dermatology Research and Practice No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-454587
American Medical Association (AMA)
Li, Jifen& Radice, Glenn L.. A New Perspective on Intercalated Disc Organization : Implications for Heart Disease. Dermatology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-454587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454587